| 摘要: |
| 原虫是一种单细胞真核生物,整个虫体由一个细胞构成,可以寄生在机体的腔道、体液、组织或细胞内。原虫病严重危害人类健康和养殖业发展。目前,广泛使用的化学药物治疗会产生耐药性、药物残留和毒副作用等弊端。青蒿素作为一种从植物黄花蒿中提取的天然物质,对多种原虫具有治疗作用,与化学药物相比更加安全、廉价甚至更高效。本文对青蒿素在原虫病治疗中的作用和机理进行综述,旨在为其应用于原虫病治疗提供理论依据。 |
| 关键词: 青蒿素 作用机理 利什曼原虫 艾美尔球虫 弓形虫 疟原虫 |
| DOI： |
| 投稿时间：2016-12-21修订日期：2017-03-28 |
| 基金项目:国家“863”计划项目(2013AA102806)；国家自然科学(31272552,31272541,31672528)；吉林省科技发展计划项目(20160519011JH)和吉林省产业创新专项资金项目(2016C063)。 |
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| Research progress on therapeutic effect and mechanism of Artemisinin against protozoan infection |
| 石昊林 |
| (College of Animal Science and Technology,Jilin Provincial Engineering Research Center of Animal probiotics,Jilin Agricultural University,Changchun,Jilin,130118) |
| Abstract: |
| Protozoan is a monoplast eukaryon.The whole polypide consists of only one cell.Protozoa could live in the cavity,humor,tissue or cells of the livestock.Nowadays,there are few kinds of protozoosis jeopardizing human health and animal farming industry. However, medicines have lose their potency over time due to the development of resistance,drug remnants and side effects.Artemisinin is extracted from Artemisia annual.Compared with traditional medicine,it is safer,cheaper and more efficient. In this review,we demonstrated the mechanism of artemisinin treatment of protozoosis,the purpose is to provide some theoretical basis in use of artemisinin treatment of protozoosis. |
| Key words: Artemisinin mechanism Leishmania Eimeria tenella Toxoplasma gondii Plasmodium |
