抗病毒药物的毒性及残留检测方法研究进展

Research Development of Toxicity and Residue Detection Methods of the Antiviral Drugs

关键词:  抗病毒药物  代谢  毒性  残留检测  研究进展

Key words:  antiviral drugs  metabolism  toxicity  residue detection  research development

摘要:

曾试用于兽医临床后来又被禁用的金刚烷胺、金刚乙胺、利巴韦林、阿昔洛韦和吗啉胍等抗病毒药物,常被一些不发分子用于预防和治疗动物疾病。长期大量使用这些药物会引起动物中毒、免疫抑制、耐药性和药物残留等问题,甚至给动物疫病防控带来巨大困难。2012年的“速成鸡”事件就检出鸡肉中残留有金刚烷胺,给我国家禽业带来了负面影响。文章就常见抗病毒药物的理化性质、代谢、毒性以及残留检测方法等四个方面的研究进展进行了综述。

Abstract:

Some criminals used Amantadine, Rimantadine, Ribavirin, Aciclovir and Moroxydine to prevent and treat animal diseases. These drugs which were used with more dosage for long term may lead to animal poisoning, immunity suppression, resistance and drug residue, even difficulty in controlling animal diseases. Amantadine residue was detected in chicken in speed-up chicken affair in 2012, which had negative impact on our national poultry industry. This paper summarized the research development of the physical and chemical character, metabolism, toxicity and residue detection methods of these drugs.