| 摘要: |
| 多糖类物质是具有提高免疫力、抗病毒、抗肿瘤、抗氧化、抗炎症等广泛生理作用的生物活性成分。近年来，甘草多糖的作用受到研究人员的广泛关注，甘草多糖可以通过调节机体固有免疫、体液免疫、细胞免疫和细胞因子来增强机体免疫力，还可以通过调控机体氧化平衡、MAPK信号通路和NF-κB核因子发挥有效的抗炎作用，并具有防治骨关节炎和治疗胃炎的作用。重点阐述甘草多糖的免疫调节和抗炎作用机制，旨在为甘草多糖的进一步研究提供理论基础，并为甘草多糖的临床应用提供有价值的实践指导。 |
| 关键词: 甘草多糖 免疫调节 抗炎作用机制 细胞因子 |
| DOI： |
| 投稿时间：2020-10-12修订日期：2021-03-09 |
| 基金项目:山西省重点研发计划重点项目子项目(201603D21109-1-2)；山西省重点研发计划(201603D221008-2) |
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| Advances in Immunomodulation and Anti-inflammatory Mechanism of Glycyrrhiza Polysaccharide |
|
| (Taiyuan Normal University) |
| Abstract: |
| Polysaccharides are biological active components with a wide range of physiological functions, such as improving immunity, anti-viral, anti-tumor, anti-oxidation and anti-inflammatory. In recent years, the role of glycyrrhizin has been widely concerned by researchers. Glycyrrhiza Polysaccharide can enhance the body′s immunity by regulating innate immunity, humoral immunity, cellular immunity and cytokines. It can also play an effective anti-inflammatory role by regulating the body′s oxidative balance, MAPK signaling pathway and NF-κB nuclear factors, and can prevent and treat osteoarthritis and gastritis. This paper focuses on the immune regulation and anti-inflammatory mechanism of Glycyrrhiza Polysaccharide, in order to provide a theoretical basis for the further study of Glycyrrhiza Polysaccharide, and to provide valuable practical guidance for the clinical application of Glycyrrhiza Polysaccharide. |
| Key words: Glycyrrhiza polysaccharide immunomodulation anti-inflammatory mechanism cytokines |
