非洲猪瘟病毒入胞过程相关蛋白及分子机制的研究进展

Advances in research on proteins and molecular mechanisms of the entry of African swine fever virus

关键词:  非洲猪瘟病毒  囊膜蛋白  病毒入胞  分子机制

Key words:  African swine fever virus  envelope protein  viral endocytic process  molecular mechanism

摘要:

非洲猪瘟病毒(ASFV)是非洲猪瘟(ASF)的病原,可引发家猪和野猪急性、传染性出血死亡,目前尚无有效的疫苗和抗病毒药物。ASFV是囊膜病毒,其囊膜蛋白的结构和功能可能是影响病毒入侵和细胞嗜性的重要因素。病毒入胞是病毒感染细胞的第一步,通常是通过细胞表面特定的分子与病毒蛋白相结合吸附于宿主细胞表面,对ASFV入胞过程的病毒蛋白或宿主因子为靶点或可有效抑制ASFV的复制。本文从ASFV入胞过程中起重要作用的囊膜蛋白出发,对ASFV的入胞分子机制进行综述,为ASFV入胞深入研究以及治疗性药物和疫苗的研发提供参考。

Abstract:

African swine fever virus (ASFV) is the causative agent of African swine fever (ASF),which can cause an acute ,severe and hemorrhagic disease affecting domestic pigs and wild boars. There is currently no effective vaccine or antiviral drug. ASFV is an enveloped virus, and its envelope protein may be involved in virus invasion and cell tropism. The process of virus entry into cells is the initial step of infecting cell through binding of specific molecules on the cell surface to viral proteins and adsorbing on the host cell surface, so viral proteins or host factors that target ASFV entry may be effective in inhibiting ASFV replication. In this review we summarized the current process in molecular mechanism of ASFV entry into cells, in order to explore the perspective of ASFV membrane protein and its function which may be important for the development of therapeutic drugs and vaccines.