卡洛芬注射液辅助治疗牛细菌性呼吸疾病的疗效研究

Study on the Adjuvant Treatment of Bovine Respiratory Diseases by Carprofen Injection

关键词:  卡洛芬  奶牛  牛呼吸道疾病  临床疗效

Key words:  carprofen  dairy cow  bovine respiratory disease  clinical efficacy

摘要:

为评价卡洛芬注射液与泰拉霉素注射液联用治疗牛呼吸道疾病（bovine respiratory disease,BRD）的效果，并确定合理的给药剂量，试验选择64头患呼吸道疾病的牛，随机分为A、B两组，每组32头，其中A组皮下注射给予泰拉霉素注射液（推荐剂量2.5 mg/kgbw），同时肌内注射给予卡洛芬注射液（II期临床试验确认剂量1.4 mg/kgbw）；B组只皮下注射给予泰拉霉素注射液（推荐剂量2.5 mg/kgbw）。所有试验牛各种药均只给予1次。试验期间观察记录各组牛的临床症状，并对其进行评分；通过对各试验牛的炎症因子、致病菌、特定病原抗原/抗体的检测，评价卡洛芬注射液对牛呼吸道疾病的辅助治疗效果。试验结果显示，相比于单独使用泰拉霉素注射液，卡洛芬注射液与泰拉霉素注射液联用治疗BRD可以在更短时间内消除牛体内病原菌感染带来的炎症反应；泰拉霉素注射液单独使用或与卡洛芬注射液联用治疗BRD，给药3 d病牛的血清PCT浓度均明显下降（P＜0.05），但两药联用的下降速度更加显著（P＜0.05）。结果表明，临床上推荐卡洛芬注射液与泰拉霉素注射液联用，皮下注射，一次量为1.4 mg/kgbw，可有效辅助治疗牛呼吸道疾病

Abstract:

Abstract: The trial was designed to evaluate the efficacy of carprofen injection combined with telamycin injection in the treatment of bovine respiratory disease (BRD) and to determine the appropriate dose to administer. Six-four cattle with BRD, randomly divided into 2 groups, groups A and B, with 32 cows each, among them, group A was administered subcutaneously telamycin injection (recommended dose 2.5 mg/kg body weight) and carprofen injection (phase II confirmed dose 1.4 mg/kg body weight), group B was administered subcutaneously telamycin injection (recommended dose 2.5mg/kg body weight). All drugs were given only once in all test cattle. The clinical symptoms of each group were recorded during the trial and scored it; The adjuvant treatment efficacy of carprofen injection on bovine respiratory diseases was evaluated by the detection of inflammatory factors, pathogenic bacteria and specific pathogen antigens/antibodies in each test cattle. The results showed that carprofen injection combined with thalamycin injection to treat BRD could eliminate the inflammatory response from pathogen infection in cattle in a shorter time than thalamycin injection alone; Using thalamycin injection alone or in combination with carprofen injection for BRD, the serum PCT concentration in sick cattle decreased significantly (P<0.05), but the decrease in the two drugs was more significant (P<0.05). The results showed that carprofen injection is clinically recommended in combination with telamycin injection, one dose, 1.4 mg/kgbw, which can effectively assist in the treatment of bovine respiratory diseases.