大黄素甲醚、大黄酸的研究进展

Research Progress of Physcion and Rhein

关键词:  大黄素甲醚  大黄酸  抗病毒  抗菌  抗炎症  制备工艺  抗菌素替代

Key words:  physcion  rhein  antiviral substance  antimicrobial agent  anti-inflammatory component  workflow  alternative to antibiotics

摘要:

2014年世界卫生组织首份全球抗菌素耐药报告显示全世界面临严重的公共卫生威胁，2021年农业农村部制定了《全国兽用抗菌药使用减量化行动方案》(2021-2025)，从国家层面实施综合治理策略和措施，鼓励替代抗菌药物的研制和创新。大黄素甲醚、大黄酸作为植物蒽醌类有效成分，具有抗微生物、抗炎、抗氧化、神经保护等药理作用，但对其抗菌、抗病毒、抗炎症相关的作用机制和产业化工艺缺少详细报道。本文对国内外已经发表的专利文献、期刊文献进行综述，总结其抗菌、抗病毒、抗炎作用机制及其生产工艺，以期为进一步开发利用提供科学支撑。

Abstract:

In 2014, World Health Organization released the first global report to alert public health induced by of antimicrobial resistance. Later on, National veterinary antibiotic stewardship program (2021-2025) was implemented comprehensive measures from national strategy and to encourage development and innovation of alternative to antibiotics by Ministry of Agriculture and Rural Affairs of China in 2021.As active components of plant-derived anthraquinones, both physcion and rhein show anti-microbial, anti-inflammatory, anti-oxidation and neuroprotective activities. However, their effects on antibacterial, antiviral and anti-inflammatory and workflow remain elusive. In present review, we took effort to summary their antibacterial, antiviral, anti-inflammatory and production process, to analyze neck-bottle of industrialization based on the published patents and articles. Hopefully, our review will shed light on utilizations of physcion and rhein in future.