基于AHP-CRITIC优选清热灵口服液提取工艺

Optimization of Extraction Process of Qingreling Oral Liquid Based on AHP-CRITIC Analysis

关键词:  清热灵口服液  提取工艺  AHP-CRITIC  权重分析

Key words:  Qingreling oral liquid  extraction process  AHP-CRITIC  weight analytic

摘要:

通过比较层次分析法（AHP）、基于指标相关性的权重赋权法（CRITIC）、AHP-CRITIC混合加权法确定指标权重系数，并对正交试验各组指标成分（黄芩苷、连翘苷、出膏率）进行综合评分比较，优选清热灵口服液的提取工艺。结果显示AHP-CRITIC混合加权法科学优选出最佳提取工艺为清热灵口服液处方药材10倍加水量，提取2次，每次提取时间为1.5h，3次重复性验证试验指标成分黄芩苷、连翘苷的平均含量分别为3.2、0.12 mg/mL，平均出膏率为36.36%。AHP-CRITIC混合加权法结合正交试验确定清热灵口服液的提取工艺稳定可行，可用于产业化生产。

Abstract:

By comparing the analytic hierarchy process (AHP), criteria importance through inter-criteria correlation (CRITIC) and the AHP-CRITIC mixed weighting method, the weight coefficient of the indicator was determined, and the index components (baicalin, forsythiin, paste extraction rate) of each group in the orthogonal test were comprehensively scored and compared, and the extraction process of Qingreling oral liquid was optimized. The results showed that AHP-CRITIC mixed weighted method scientifically optimized the optimal extraction process as follows: Qingreling Oral liquid prescription medicine with 10 times of water addition, extraction twice, each extraction time is 1.5h, and the average contents of baicalin and phillyrin in 3 repeatable verification tests were 3.2 and 0.12 mg/mL, respectively. The average paste yield was 36.36%. The AHP-CRITIC mixed weighted method combined with orthogonal test determined that the extraction process of Qingreling oral liquid was stable and feasible, and could be used for industrial production.