恩诺沙星和环丙沙星在肉鸡体内残留与代谢研究进展

Research Progress on the Metabolism and Residue Elimination of Enrofloxacin and Ciprofloxacin in Broilers

关键词:  鸡  抗菌药物  代谢转化  残留消除

Key words:  chicken  antibacterial drugs  metabolic transformation  residue elimination

摘要:

本文综述了恩诺沙星与环丙沙星两种常用的喹诺酮类药物在肉鸡体内残留与代谢物检测方面的研究进展，研究方法主要包括：高效液相色谱法、液相色谱-串联质谱法、胶体金标记单克隆抗体及竞争抑制方法，并探究恩诺沙星、环丙沙星在不同品类鸡中代谢分布与残留消除规律的异同，对恩诺沙星和环丙沙星代谢产物进行归纳总结，为进一步研究喹诺酮类药物在不同品类肉鸡中的残留与代谢物检测提供参考。

Abstract:

In this paper, the research progress of the determination of residues and metabolites of two commonly used quinolones including enrofloxacin and ciprofloxacin in broilers was reviewed. The research methods mainly included high-performance liquid chromatography, liquid chromatography-tandem mass spectrometry, colloidal gold-labeled monoclonal antibody, and competitive inhibition method. The differences and similarities of enrofloxacin and ciprofloxacin metabolism, distribution and residue elimination in different types of broiler were explored, and the metabolites of enrofloxacin and ciprofloxacin were summarized. The purpose of this review is to provide a reference for further study of quinolone residues and metabolites detection in different types of broiler.