| 摘要: |
| 马波沙星作为一种专用于动物的新型第3代氟喹诺酮类广谱抗菌药，其可作用于狗、猫、猪、牛等动物的呼吸道、消化道、泌尿道及皮肤感染问题，具有吸收快速且彻底、对组织渗透性强、分布范围广泛特点，同时，其在血浆和组织中的含量较高，可消除半衰期长、生物利用率高的良好特性。本文主要对马波沙星的作用机制、药动学、药效学及临床使用、不良影响及注意事项进行综述，为马波沙星在临床使用中提供一定的参考价值。 |
| 关键词: 马波沙星 作用机制 药动学 药效学 不良影响 |
| DOI： |
| 投稿时间：2021-12-12修订日期：2022-10-20 |
| 基金项目: |
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| Research Progress on Marbofloxacin |
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| (Shandong Institute of Commerce & Technology) |
| Abstract: |
| As a new animal dedicated third-generation broad-spectrum fluoroquinolone, marbofloxacin is mainly used for respiratory, digestive tract, urinary tract and skin infection of dogs, cats, swine and cattle. The excellent characteristics of marbofloxacin are as follows: fast and complete absorption, perfect tissue penetration, extensive distribution, high concentration in plasma and tissues, long elimination half-life time, high bioavailability and so on. In this paper, the mechanism of action, pharmacokinetics, pharmacodynamics, clinical use, adverse effects and precautions of marbofloxacin were reviewed to provide some reference value for the clinical use of marbofloxacin. |
| Key words: marbofloxacin action mechanism pharmacokinetics pharmacodynamics adverse effects |
