非洲猪瘟病毒入侵细胞机制的研究进展

Research Progress on the Mechanism of African swine fever virus Invading Cells

关键词:  非洲猪瘟病毒  病毒入侵  巨噬细胞  Vero细胞  内化

Key words:  African swine fever virus  Virus invasion  Macrophages  Vero cells  Internalization

摘要:

病毒进入宿主细胞的机制决定了病毒的趋向性和发病机理,病毒感染细胞包括吸附、穿入、脱壳、复制、组装及子代病毒颗粒的释放等步骤,对病毒入侵机制研究可以为开发有针对性的预防策略提供思路。非洲猪瘟病毒作为一种有囊膜双链DNA病毒,其入侵宿主细胞的机制与其他病毒有一定的相似之处,同样也有其特殊性。目前,人们对非洲猪瘟病毒与宿主细胞相互作用,特别是入侵机制的了解仍然非常有限。为此,本文就ASFV入侵细胞的有关研究进展进行了综述,以期为非洲猪瘟病毒致病机制相关研究提供参考。

Abstract:

The mechanism of the virus invading the host cell determines the tendency and pathogenesis of the virus. The virus infecting cells include the steps of adsorption, penetration, unpacking, replication, assembly and release of offspring virus particles. The study of the invasion mechanism of the virus can provide ideas for the development of targeted prevention strategies. The mechanism of African swine fever virus invading host cells is similar to other viruses, and it has the particularity as a with capsule double-stranded DNA virus. At present, the knowledge of the interaction of the African swine fever virus with the host cells, especially the invasion mechanism, remains very limited. Accordingly, the research progress of ASFV invasion cells is reviewed in this paper.