| 摘要: |
| 小反刍兽疫(PPR)是由小反刍兽疫病毒(PPRV)引起的山羊、绵羊等小反刍动物的急性、高度接触性传染病。反向遗传学是在获得生物基因信息的基础上，对基因进行突变、缺失等操作，进而研究基因变化对表型的影响。本文综述了包括PPRV在内的单股负链RNA病毒反向遗传学的最新研究进展，以期为PPRV及同科属病毒的反向遗传操作系统的建立提供新的思路。 |
| 关键词: 小反刍兽疫病毒 单股负链RNA病毒 反向遗传学 |
| DOI： |
| 投稿时间：2021-10-13修订日期：2022-01-04 |
| 基金项目:中国兽医药品监察所兽药行业公益性重点专项—小反刍兽疫病毒反向遗传操作系统的构建及可鉴别感染与免疫检测技术的建立（P2021012020） |
|
| Research Progress on Reverse Genetics of Peste Des Petits Ruminants Virus |
|
| (China Institute of Veterinary Drug Control) |
| Abstract: |
| Peste des petits ruminants (PPR) is an acute and highly contact infectious disease of goats, sheep and other small ruminants caused by the Peste des petits ruminants virus (PPRV). Reverse genetics is based on obtaining biological genetic information, performing operations such as mutations and deletions on genes, and then studying the impact of genetic changes on phenotypes. This article reviews the latest research progress in reverse genetics of single-stranded negative-strand RNA viruses, including PPRV, in order to provide new ideas for the establishment of reverse genetic operating systems for PPRV and viruses of the same family. |
| Key words: Peste des petits ruminants virus Single-stranded negative-strand RNA virus reverse genetics |
