恩拉霉素提取工艺研究

Extraction Technology of Enramycin

关键词:  恩拉霉素  提取工艺  甲醇

Key words:  Enramycin  extraction  methanol solution

摘要:

为优化恩拉霉素提取工艺，以70%甲醇溶液为提取剂，提取恩拉霉素，经过浓缩、脱色、结晶、重结晶，制备高含量恩拉霉素产品。得到最佳提取工艺条件是：浸提pH3.5~4.0，浸提温度30 ℃，三次浸提时间1 h，一次浸提料液比1∶7，二次浸提料液比1∶3，三次浸提料液比1∶3，活性炭用量是浓缩液体积的1.0%~1.5%，粗精粉重结晶得到纯品，含量97%。

Abstract:

To optimize extraction technology of Enramycin, 70% methanol solution was used to extract Enramycin, and then was concentrated, decolorized, crystallized, recrystallized. The active pharmaceutical ingredient (API) was produced. The optimized extraction technological conditions were pH 3.5~4.0, temperature 30℃, extraction time1h, three extraction process ed with material-liquid ratios 1∶7, 1∶3, 1∶3，1.0%~1.5% ratio of activated carbon / concentrated solution, recrystallized once. The product of Enramycin was 97%.