| 摘要: |
| 作为一种新型非甾体抗炎药,阿司匹林丁香酚酯已被证实具有抗炎、镇痛、抗血管内皮氧化、抗血栓、抗动脉粥样硬化、解热等药理活性,相比前药不仅具有低毒、作用时间长、安全范围广等特性,而且克服了前药的不良药物性质。本文将就AEE目前已经研究的毒理学、药物代谢、药代动力学,及其抗动脉粥样硬化、抗血栓、抗血管内皮细胞氧化等药理学研究进展进行综述。 |
| 关键词: 阿司匹林丁香酚酯 阿司匹林 丁香酚 抗炎 抗血管内皮氧化 |
| DOI： |
| 投稿时间：2020-06-08修订日期：2020-09-12 |
| 基金项目:国家自然科学(31872518) |
|
| Advances in the research of aspirin eugenol ester, a new non –steroidal anti - inflammatory drug |
|
| (Key Lab of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs,Key Lab of New Animal Drug Project of Gansu Province,Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS) |
| Abstract: |
| As a new type of non-steroidal anti-inflammatory drug, aspirin eugenol ester has been proved to have anti-inflammatory, analgesic, anti-vascular endothelial oxidation, anti-thrombus, anti-atherosclerosis, antipyretic and other pharmacological activities. compared with the prodrug, it not only has the characteristics of low toxicity, long action time and wide safety range, but also overcomes the adverse drug properties of the prodrug. This article reviews the toxicology, drug metabolism, pharmacokinetics, anti-atherosclerosis, anti-thrombus, anti-oxidation of vascular endothelial cells and other pharmacological research progress of AEE. |
| Key words: aspirin eugenol ester aspirin eugenol anti-inflammatory anti-vascular |
