| 摘要: |
| 为了优化中药复方催情颗粒的制备参数,试验采用湿法制粒,通过单因素试验和正交试验优选药物与辅料及辅料间的比例、乙醇浓度和乙醇用量三个因素,通过颗粒的成型率、堆密度和休止角来评价颗粒的最佳成型工艺。结果显示药物与辅料比为1：1,乙醇浓度为80%,乙醇用量为(干料：乙醇)1:0.3,制备的颗粒剂综合评分最高。中药复方催情颗粒的制备工艺优化为其临床中试试验的扩大生产提供了参考依据。 |
| 关键词: 颗粒剂 正交实验 制备工艺 |
| DOI： |
| 投稿时间：2020-05-07修订日期：2020-10-23 |
| 基金项目:吉林化工学院2019年大学生创新训练计划；中药防治蛋鸡输卵管炎研发横向课题(K19LD3001) |
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| Optimization of the Preparation Technology for Estrus Granules |
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| (School of Chemistry and Pharmaceutical Engineering,Jilin Institute of Chemical Technology) |
| Abstract: |
| In order to optimize the preparation technology for estrus granules, the dry granulating was used, the ratio of medicine and excipient, ethanol concentration and ethanol volume were optimize by single factor tests and orthogonal test, and the molding ratio, bulk density and angle of repose was determined. The results showed the optimized preparation technology of estrus granules was the ratio of medicine and excipient was 1:1, ethanol concentration 80% and ethanol volume(dry powder: ethanol)1:0.3. The optimized preparation technology provided reference for clinical pilot test of estrus granules |
| Key words: Granules Orthogonal test Preparation technology |
