引用本文
  •    [点击复制]
  •    [点击复制]
【打印本页】 【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 116次   下载 159 本文二维码信息
码上扫一扫!
加味当归四逆壳聚糖喷膜剂的研制
车妤杰,彭佳昊,王浩嘉,刘诗雨,杜昊男,舒刚,吕程
0
(四川农业大学动物医学院)
摘要:
研制加味当归四逆壳聚糖喷膜剂,并且制定生产工艺和质量标准。试验采用水煎法提取处方药材;通过正交试验确定壳聚糖盐酸盐、PVPK-30以及乙醇成膜材料的最佳配比;按照药典相关规定,采用紫外分光光度法测定每瓶总黄酮的含量。成膜材料的最佳配比为壳聚糖盐酸盐1%,3%PVPK-30和40%乙醇。通过TLC鉴定样品含有阿魏酸和芍药苷成分。质量标准中性状为澄清有清凉气味的红棕色液体,总黄酮的含量1.83 mg/mL。以处方为219 mg/mL中药复方,1%的壳聚糖盐酸盐,3%的PVPK-30以及40%的乙醇制备出加味当归四逆壳聚糖喷膜剂,且制定质量标准中样品含有阿魏酸和芍药苷并且每瓶总黄酮含量满足1.83 mg/mL。
关键词:  加味当归四逆汤  喷膜剂  壳聚糖盐酸盐  总黄酮  质量标准
DOI:
投稿时间:2019-07-26修订日期:2019-11-19
基金项目:国家级大学生创新创业训练项目(201810626088)
Study on modified Danggui Sini Decoction with chitosan hydrochloride spray film agent1
(School of Animal Medicine, Sichuan Agricultural University)
Abstract:
To develop a modified Danggui Sini Decoction with chitosan hydrochloride spray film agent, and formulate productive technology and quality standards. The prescription medicines were extracted by water decoction method; the optimum proportion of film-forming materials including chitosan hydrochloride, PVPK-30 and ethanol was determined by orthogonal test; according to the relevant provisions of pharmacopoeia, the content of total flavonoids in each bottle was determined by ultraviolet spectrophotometry. The optimum proportion of film-forming materials is 219 mg/mL Chinese herbal compound, 1% chitosan hydrochloride, 3% PVPK-30 and 40% ethanol. The samples were identified to contain ferulic acid and paeoniflorin by TLC. In the quality standard, the total flavonoids content of each bottle was 1.83 mg/mL. Modified Danggui Sini Decoction with chitosan hydrochloride spray film agent was prepared with 1% chitosan hydrochloride, 3% PVPK-30 and 40% ethanol. The sample contained ferulic acid and paeoniflorin , and the total flavonoid content in each bottle was 1.83 mg/mL.
Key words:  Modified Danggui Sini Decoction  spray film agent  chitosan hydrochloride  total flavonoids  quality standard

用微信扫一扫

用微信扫一扫