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玉屏风散与微粉中毛蕊异黄酮葡萄糖苷体外溶出率的研究
马霞,周延州,郭振环,赵丽,刘永录,王林,张国祖
0
(河南牧业经济学院;河南省康星生物科技有限公司;河南省康星药业股份有限公司)
摘要:
建立了玉屏风超微粉中毛蕊异黄酮葡萄糖苷的高效液相色谱检测方法,采用浆法测定了玉屏风超微粉和玉屏风散剂在人工胃液中的溶出率,绘制累积溶出率曲线。结果表明,玉屏风超微粉和散剂散剂的累积溶出率在5 min时迅速达到73%以上。超微粉和散剂的最快溶出时间段分别为0~2 h和0~6 h,最后都在16 h达到溶出平衡,最高累积溶出率分别为80.36%和77.51%。玉屏风超微粉中毛蕊异黄酮葡萄糖苷溶出速度快,达峰时间短,峰浓度高于散剂。
关键词:  玉屏风微粉  毛蕊异黄酮葡萄糖苷  含量  检测方法  溶出率
DOI:
投稿时间:2019-07-06修订日期:2019-10-18
基金项目:河南牧业经济学院“中兽药生药学”重点培育学科项目(HUAHF4100003);河南牧业经济学院科研创新团队项目(2018KYTD18)
Study on the Dissolution Rate of Hairy Isoflavone Glucoside in Yupingfeng San and Ultra-micropowder
(Henan University of Animal Husbandry and Economy)
Abstract:
This research establish the determination method of Hairy Isoflavone Glucoside content in yupingfeng ultra-micropowder by HPLC. The dissolution rates of yupingfeng ultra-micropowder and common powder were detected by pulp method, and the curve of cumulative dissolution rate was charted. The results showed that the cumulative dissolution rate of yupingfeng ultra-micropowder and common powder were over 73% in 5 minutes. The fastest dissolution time were 0-2h and 0-6h, and they both achieve dissolution equilibrium in 16h, the most cumulative dissolution rate were 80.36% and 77.51%.The dissolution rate of calycosin-7-glucoside in yupingfeng ultra-micropowder was quicker, it had shorter peak time, and the peak concentration was higher than common powder.
Key words:  Yupingfeng Ultra-micropowde  Hairy Isoflavone Glucoside  Content  Determination  Dissolution Rate

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