泰地罗新注射液在藏鸡体内的药动学研究

Studies on Pharmacokinetics of Tildipirosin Injection in Tibetan Chicken

Key words:  Tildipirosin  HPLC  Tibetan Chicken  pharmacokinetics

摘要:

为研究泰地罗新注射液在藏鸡体内的药物动力学特征,了解其在藏鸡体内的吸收、分布、转化及排泄规律,为新兽药的研发和临床用药提供参考。本试验选取藏鸡12羽,泰地罗新单剂量注射给药(4 mg/kg.bw),不同时间点采集藏鸡血液,利用高效液相色谱法测定血浆中药物浓度。结果表明：泰地罗新注射给药后,泰地罗新在藏鸡体内的药-时曲线符合有吸收三室开放模型,其主要药动学参数为：Tmax为1.727±0.237 h,Cmax为0.938±0.121 μg/mL,t1/2为36.198±2.394 h,AUC为55.564±3.675 μg.h/mL, Vd为16.155±2.676 mL/kg。表明泰地罗新注射给药后,在藏鸡体内吸收迅速,消除较为缓慢,对新兽药的研发和临床合理使用具有一定的指导意义。

Abstract:

The paper mainly aims at exploring characteristic of pharmacokinetics for Tildipirosin Injection, as well as its regulation of absorption, distribution, transformation and excretion of the Tibetan Chicken, thus providing reference for research and development of new veterinary drug and clinical medication for Tildipirosin injection. This study selects 12 Tibetan Tibetan Chicken for single dose Tildipirosin injection with blood collection at different time points, for determination of drug concentration in plasma by hplc. The results show that vivo drug time curve of Tildipirosin in Tibetan Tibetan Chicken corresponds with absorption three compartment open model after injection of Tilipirosin, with their main pharmacokinetics parameters: Tmax 0.457 +0.143h, Cmax 0.759+0.192 g/mL, t1/2 120.518+10.181h. AUC 22.224+2.641μg.h/mL, Vd 16.155±2.676 mL/kg. It shows that Tildipirosin, injected in Tibetan Tibetan Chicken, is quickly absorbed but slowly eliminated in Tibetan Tibetan Chicken, thus playing a certain guidance role in research and development and clinical rational use of new veterinary drug.