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复方芩兰口服液长期毒性试验研究
贾兴,刘欣,魏丽娟,耿志霞,瞿红颖,宋婷婷,刘静,魏占勇,史万玉
0
(河北远征药业有限公司)
摘要:
为了考察复方芩兰口服液的安全性,以大鼠为试验动物,分别在其饮水中连续添加20mL/L(拟推荐剂量10倍)、40mL/L(拟推荐剂量20倍)、80mL/L(拟推荐剂量40倍)的复方芩兰口服液,对其长期毒性进行了为期4周的饲喂考察。结果显示,复方芩兰口服液的所有用药组大鼠,在为期28d的试验过程中,其临床表现、增重及饲料利用、脏器指数、血液学常规、血液生化检查及组织病理学六方面均与对照组无显著差异(P>0.05),表明该药长期使用是安全的。
关键词:  复方芩兰口服液  长期毒性  大鼠
DOI:
投稿时间:2019-02-28修订日期:2019-06-22
基金项目:
Fufang Qinlan Oral Liquid Long-termToxicity Test
(Hebei Yuanzhoang Phamaceutical CO.,LTD)
Abstract:
In order to investigate the safety of Fufang Qinlan oral liquid, rats were used as test animals. Fufang Qinlan oral liquid was continuously added in rats drinking water with the concentration of 20mL/L (10 times recommended dose), 40mL/L (20 times recommended dose), and 80mL/L (40 times recommended dose) in the long-term toxicity test, and conducted a four-week feeding study. Conducted a four-week feeding study. In the 28-day trial, the results showed that the clinical manifestations, weight gain and feed utilization, organ index, hematology routine, blood biochemical examination and histopathology of all the experimental group were not significantly different from the control group ( P>0.05). It indicates that the long-term use of Fufang Qinlan oral liquid is safe.
Key words:  Fufang Qinlan oral liquid  long-term toxicity  rats

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