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牛蒡子提取物长期毒性试验研究
何斌,张海静,杨文海,吴利军,邵志勇,陈夏冰,陈洁,金尔光,操继跃
0
(武汉市农业科学院畜牧兽医研究所;华中农业大学)
摘要:
为评价牛蒡子提取物在兽医临床使用中的安全性,根据兽药长期毒性试验指导原则的方法,对SPF级Wister大鼠进行了牛蒡子提取物6g/kg.bw、3g/kg.bw、1.5g/kg.bw剂量灌胃给药的30d长期毒性试验。试验结果表明:试验各组大鼠活动正常,精神状态良好,均未出现死亡情况和明显中毒症状;牛蒡子提取物给药组与对照组比较,大鼠体重、进食量、饲料利用率、血常规、血液生化、脏器重量、脏/体比值等指标差异均不显著,大体解剖均未发现异常,对高剂量组和空白组进行病理组织学检查并进行病理积分,两组比较差异不显著,结果为未发现牛蒡子粉有明显毒性作用。
关键词:  牛蒡子提取物  Wister大鼠  30d长期毒性
DOI:
投稿时间:2019-02-26修订日期:2019-04-28
基金项目:
Study on The Long-term Toxicity of Arctium Lappa Extract
(Institute#$NBSof#$NBSAnimal#$NBSHusbandry#$NBSand#$NBSVeterinary,Wuhan#$NBSAcademy#$NBSof#$NBSAgricultural#$NBSSciences)
Abstract:
In order to evaluate the safety of arctium lappa extract in veterinary clinical use, the long-term toxicity test of 6g/kg.bw, 3g/kg.bw and 1.5g/kg.bw of arctium lappa extract was conducted in SPF Wister rats according to the guidelines for long-term toxicity test of veterinary drugs. The results showed that the rats in each group had normal activities and good mental state, and no death or obvious poisoning symptoms were found. Extracts from fructus arctii drug group compared with control group, the rat body weight, food intake, feed utilization, routine blood, blood biochemistry, organ, the dirty/body weight ratio index were not significant difference, such as gross anatomy are no abnormalities are found, the high dose group and blank group, histologic examination and pathological integral is similar between the two groups was not significant, the result is not found fructus arctii powder has obvious toxic action.
Key words:  Burdock seed extract  Wister rats  Long-term toxicity at 30d

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