细菌活载体疫苗的研究进展

Advances of Live Bacterial Vector Vaccine

关键词:  细菌活载体疫苗  免疫应答  研究进展

Key words:  live bacterial vector vaccine  immune response  research status

摘要:

细菌活载体疫苗是指将某一病原体的保护性抗原或表位插入细菌基因组或其质粒的某些部位，使其直接表达外源抗原或将携带的外源DNA递呈到宿主细胞的重组细菌。细菌活载体疫苗能够诱导机体产生粘膜免疫、体液免疫和细胞免疫，是目前传染病预防控制、肿瘤免疫治疗、免疫调节等方面的重要研究方向之一。本综述从细菌活载体疫苗的构建及应用两个方面进行系统介绍，以期为细菌活载体疫苗的研究与应用提供一定的参考。

Abstract:

The bacteria engineered to deliver plasmids or carry heterologous gene which we can also call live bacterial vector could stimulate the host’s broad-based immune system by expressing heterologous antigen ,while still offering good levels of safety.The live bacterial vector vaccines which have become a trend in the development of biological products industry are promising candidates for plague prevention and tumor immunotherapy.Genetic technologies are evolving,which potentiate the development of the live bacterial vector vaccines.There is a brief overview of the construction,characteristics and the research status of live bacterial vaccine vector.