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柴黄口服液对靶动物鸡安全性试验研究
刘毅,张国荣,耿智霞,贾兴,瞿红颖,刘欣,宋婷婷,刘静,魏丽娟,史万玉
0
(河北远征药业有限公司)
摘要:
为研究柴黄口服液对靶动物鸡的安全性,将80只雏鸡随机分为四组。分别在饮水中添加0、1、3和5倍推荐剂量(0 ml/L、1 ml/L、3ml/L、5ml/L)的柴黄口服液,连续给药42 d。每天观察并记录各组鸡的临床体征,每周末称重1次,试验结束时测定各组鸡的血液生理生化指标,同时进行剖检。结果发现,柴黄口服液各剂量组鸡的精神状态、生长发育、血液生化生理指标、剖检以及组织显微结构等均未见明显异常,未出现中毒症状及死亡。结论:柴黄口服液对靶动物鸡未见明显毒副作用,在临床上以1 ml/L在鸡饮水中混饮是安全的。
关键词:  柴黄口服液    靶动物  安全性
DOI:
投稿时间:2018-12-29修订日期:2019-05-05
基金项目:
Target Animal Safety Study on Chaihuang Oral Solution in Chickens
(Hebei Yuanzheng Pharmaceutical Co., Ltd.)
Abstract:
In order to evaluate the target animal safety on Chaihuang oral solution in chickens, 80 chicks were randomly divided into four groupsp. Chickens were treated with 0, 1, 3 and 5 times recommended doses (0 ml/L,1 ml/L,3ml/L,5ml/L) of Chaihuang oral solution to drinking water for 42 days respectively. The clinical signs of each group of chickens were observed and recorded every day and weighed once every weekend. At the end of the experiment, the blood physiological and biochemical indexes of each group of chickens were measured and dissected at the same time. The results showed that the mental state, growth and development, blood biochemical and physiological indexes, dissection, and tissue microstructure of different dose groups of Chaihuang oral solution were found no significant abnormalities and no toxic symptoms or death were found. Conclusion: Chaihuang oral solution has no obvious toxicity and side effect on the target animal chickens. It is safe to mix 1 ml/L Chaihuang oral solution in chicken drinking water clinically.
Key words:  Chaihuang oral solution  chickens  target animal  safety

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