包膜丁酸钠与癸氧喹酯联合应用抗鸡球虫作用研究

Anticoccidial Effect of Coated Sodium Butyrate Combined with Decoquinate in Chickens

关键词:  鸡  球虫  包膜丁酸钠  癸氧喹酯

Key words:  chicken  coccidia  coated sodium butyrate  decoquinate

摘要:

以柔嫩艾美耳球虫（E.tenella）口服接种建立雏鸡球虫感染模型，分为空白组，感染对照组，包膜丁酸钠（CSB，750 mg/kg）组，癸氧喹酯（DQ，40 mg/kg）组和联合用药组。在接种前1d至接种后6d拌料投喂CSB、DQ单用或联合用药，通过临床症状，粪便卵囊计数、盲肠病变记分以及盲肠组织病理观察来评价药物的抗球虫作用。结果表明：感染对照组和CSB处理组在感染后第5-6 d均出现了大量血便，但CSB组推迟并减少了卵囊排出，DQ单用以及与CSB联合用药都明显推迟并减少了血便，盲肠病变记分也相应减轻，且联合用药组未见卵囊排出。盲肠组织HE染色结果与临床症状一致，联合用药组防治效果最佳。这表明单用CSB虽不能预防球虫病的发生，与DQ合用时有一定的增效作用。

Abstract:

Chickens were orally infected with Eimeria tenella (E. tenella) to establish chicken coccidiosis model. They were randomly assigned to Control,E. tenella infection (EI)-treated,Coated sodium butyrate (CSB,750mg/kg)-treated,decoquinate (DQ,40mg/kg)-treated and CSB combined with DQ-treated groups. Chickens were given diets mixed with CSB and DQ alone or their combination from the day before inoculation to the 6th day after inoculation. Clinical symptoms, oocysts per gram (OPG), lesion scores and cecum histopathological observation were assessed．Results indicated that on 5-6 days post inoculation, EI-treated group and CSB-treated group appeared severe bloody feces, but CSB-treatment delayed and reduced oocyst discharge. Moreover the bloody feces and pathological changes of cecum section were attenuated in DQ-treated group and CSB combined with DQ-treated group. The results show that CSB alone can’t prevent coccidiosis, however, combined application of DQ and CSB has a certain synergy effect.