伊维菌素在不同动物中安全性、药效学和药代动力学的差异性研究进展

Research Progress on the Difference of Safety, Pharmacodynamics and Pharmacokinetics of Ivermectin in Various Animals

关键词:  伊维菌素  安全性  药效  药代动力学  差异

Key words:  ivermectin  safety  pharmacodynamics  pharmacokinetics  difference

摘要:

伊维菌素是一种被广泛应用于多种畜禽线虫病和外寄生虫病防控的抗寄生虫药物。由于伊维菌素具有非常突出的优点，在不同种属动物上使用时，其安全性、药效学和药代动力学的差异更容易被人们忽略。忽略动物种属差异，可能会导致寄生虫病防治失败，甚至安全事故的发生。本文将对伊维菌素在不同动物中的安全性、药效学和药代动力学差异做一综述，以期为伊维菌素的临床用药提供参考，保障伊维菌素在不同动物中用药的安全性和有效性。

Abstract:

Ivermectin is an antiparasitic agent which has been widely used in various livestock to control nematodes and ectoparasites infection. Due to its outstanding properties, the difference of safety, pharmacodynamics and pharmacokinetics of ivermectin in various animals is easily to be ignored by people, probably leading to failed control of parasitic disease or even the occurrence of safety accidents. This article will make a review of the difference of safety, pharmacodynamics and pharmacokinetics of ivermectin in various animals in order to provide a reference for the clinical application of ivermectin and ensure its safety and effectiveness of ivermectin in different animals.