桉油溶液剂的急性毒性和安全药理学研究

Pharmacology Studies on Acute Toxicity and Safety of Eucalyptus oil Solution

关键词:  桉油溶液剂  急性毒性  安全药理学

Key words:  Eucalyptus oil solution  Acute toxicity  Safety pharmacology

摘要:

本实验室制备的桉油溶液剂经生产实践和兽医临床试验证明具有良好的治疗动物疥螨病效果。为进一步临床试验并了解桉油溶液剂的安全性，对其进行了急性毒性试验以及安全药理学研究。通过灌胃给药(ig)研究桉油溶液剂对大鼠的急性毒性。安全药理学试验以高剂量（30%）、中剂量（18%）、低剂量（6%）分别给予大鼠0.3 ml/只涂抹桉油溶液剂，观察其对大鼠神经系统、心血管系统和呼吸系统的影响。桉油溶液剂对大鼠的经口半数致死量（LD50）为3811.5 mg/kg。桉油溶液剂对大鼠的中枢神经系统、呼吸系统和心率等均无明显影响。桉油溶液剂是一种较安全的局部外用药，适合在临床上推广应用。

Abstract:

It has been proved that eucalyptus oil solution produced in our laboratory presenting good results in treating sarcoptidosis. In order to study the clinical effect and the acute toxicity of Eucalyptus oil solution, the acute toxicity and the safety pharmacology was tested. We observed the acute toxicity of imperatorin by perfusing intragastric administration(ig) to rats. In safety pharmacology experiments, high dose group(30%), middle dose group(18%) and low dose group(6%) of eucalyptus oil solution were respectively applied on the skin of rats 0.3 ml/ench and then we observed the influences on the nervous system, cardiovascular and respiratory systems of targeted rats. The LD50 of eucalyptus oil solution to rats is 3811.5 mg/kg by ig. There is no significant effect on the nervous system, cardiovascular and respiratory systems of targeted rats according to the experiment. Eucalyptus oil solution is a comparatively safe foreign agents and suitable for further clinical promotion.