中药多糖对巨噬细胞和树突状细胞免疫调节作用的研究进展

Advances in immunoregulation of macrophages and dendritic cells by polysaccharides from traditional Chinese medicine

关键词:  中药多糖、巨噬细胞、树突状细胞、信号通路、免疫调节

Key words:  Chinese medicine polysaccharide  macrophages  dendritic cells  signal pathway  immunoregulation effects

摘要:

中药多糖有安全、无副作用及显著的免疫刺激效应的特点,是理想的免疫调节剂。目前对中药多糖免疫调节作用的研究多集中在抗体水平、器官指数等免疫指标的影响,为了揭示中药多糖的免疫调节机制,需进一步研究中药多糖对巨噬细胞及树突状细胞的免疫调节作用,尤其是信号通路。目前研究表明中药多糖能够通过Toll样受体、蛋白激酶C(PKC)、甘露糖受体等不同的信号通路激活、诱导巨噬细胞及树突状细胞的成熟,减少树突状细胞的内吞作用,增强巨噬细胞吞噬能力及T细胞增殖力,促进细胞因子的释放等作用。本文主要从机体在正常情况、LPS诱导的炎症条件及对多糖进行不同的化学修饰下中药多糖对巨噬细胞及树突状细胞的免疫调节作用进行综述。

Abstract:

Chinese medicine polysaccharide has the characteristics of safe, no side effects and significant immune stimulating effect, which is the ideal immunomodulator. At present, the study on the immunoregulatory effect of polysaccharides in Chinese medicine is focused on the effects of immune indexes such as antibody level and organ index. In order to reveal the immune regulation mechanism of polysaccharides, it is necessary to further study the immunoregulation effect of polysaccharides on macrophages and dendritic cells, especially the signal pathway. Studies have shown that traditional Chinese medicine polysaccharides can be through the Toll-like receptor, protein kinase C (PKC), mannose receptor and other different signaling pathway activation, induced macrophages and dendritic cells mature, reduce in the endocytosis of dendritic cells , enhance macrophage phagocytosis and T cell proliferation, and promote the release of cytokines and so on. In this paper, we mainly reviewed the immunoregulation effects of polysaccharides from traditional Chinese medicine on macrophages and dendritic cells when the body is healthy or under the inflammatory situation induced by LPS and the polysaccharides under different chemical modifications.