碱偏离型恩诺沙星注射液的临床应用研究

The?Clinical?Application?Study?on?Alkali?Deviation?Type?Enrofloxacin? Injection

关键词:  碱偏离型恩诺沙星注射液  大肠杆菌病  预防和治疗试验

Key words:  alkali deviation typeenrofloxacin?injection  ?colibacillosis  ? prevention?and?treatment test

摘要:

为了研究碱偏离型恩诺沙星注射液对人工感染大肠杆菌O78雏鸡的治疗作用，本试验以8日龄的雏鸡为试验动物，腹腔注射一定剂量的O78菌悬液，建立雏鸡大肠杆菌人工感染模型，然后给予不同剂量碱偏离型恩诺沙星注射液对其进行治疗试验。结果显示，给予1.75mg/kg碱偏离型恩诺沙星注射液进行预防给药，其增重率显著升高，增重率和有效率分别为102.45%和100%；给予1.75mg/kg碱偏离型恩诺沙星注射液进行治疗给药，雏鸡增重率、治愈率和有效率分别为93.34%、70%和83%，试验证明，碱偏离型恩诺沙星注射液能有效防治人工感染雏鸡大肠杆菌病，为兽医临床应用碱偏离型恩诺沙星注射液治疗雏鸡大肠杆菌病提供了理论依据。

Abstract:

To?study the therapeutic effect of alkali deviation type enrofloxacin in chicken which were infected artificially with the O78 E.coli (Escherichia coli), 8-day-old chicken were choosed to take intraperitoneal injection of a certain dose of O78 E.coli bacterial?suspension to establish E.coli infection model. And then chicken were treated with various doses of alkali deviation type enrofloxacin injection. The?result?showed?that the?weight?gain?rate improved significantly with alkali deviation type enrofloxacin?injection (1.75mg/kg)?treated for prevention. The?weight gain?rate?and?the?effective?rate was respectively 102.45%?and?100%?. While the?weight?gain?rate,?the?effective?rate?and the?cure?rate?was respectively?58.34%,?70%?and?83% with alkali deviation type enrofloxacin?injection (1.75mg/kg)?treated for therapy.?The?experiment?showed?that the alkali deviation type enrofloxacin?injection?has obvious?therapeutical?effect?on?colibacillosis infected artificially with??O78 E.coli, which?provided?theoretical?support?in clinical usage.