| 摘要: |
| 为了解潮霉素B预混剂临床驱除绦虫线虫的有效性和给药时间的合理性，依据兽药临床试验规范，试验选择了蠕虫自然感染皖西麻黄鸡824只，按要求随机分为3组，分别为潮霉素B预混剂治疗组284只，芬苯哒唑粉对照药物组284只，不治疗的感染对照组256只，试验周期根据临床治疗效果确定。结果显示，潮霉素B预混剂，推荐剂量10mg/kg混饲，连续饲喂21 d，对鸡蛔虫和绦虫的粗计驱虫率分别为63%和26%，表现明显的驱除蛔虫作用（P<0.05），连续饲喂42 d，对鸡蛔虫和绦虫的粗计驱虫率分别为100%和-13%，驱蛔虫效果极显著（P<0.01）；对照药物芬苯哒唑粉，50mg/kg混饲，连续饲喂6 d，对鸡蛔虫和绦虫的粗计驱虫率分别为100%和44%，同样具有极显著的驱除蛔虫作用（P<0.01），本试验中2种药物的驱蛔虫效果相当，对绦虫的驱除作用不明显（P>0.05）。潮霉素B预混剂10mg/kg混饲，连续饲喂42 d，可以驱净鸡蛔虫的感染，但对鸡绦虫感染无明显的驱除作用。 |
| 关键词: 鸡蛔虫 潮霉素B 临床试验 |
| DOI： |
| 投稿时间：2016-09-18修订日期：2017-01-03 |
| 基金项目:国家自然科学基金项目（31272607），国家重点研发计划专项（2016YFD0501303），农业部公益性行业专项（201303038-9） |
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| Clinical deworming trial on hygromycin B premixes |
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| (Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences/Key Laboratory of Veterinary Drug Safety Evaluation and Residues Research/Key Laboratory of Animal Parasitology of Ministry of Agriculture) |
| Abstract: |
| To understand the clinical effect and rational administration time of hygromycin B premixs expelling the Taenia and Nematodes. 824 Wanxi partridge chicken naturally infected by worms were selected and randomly assigned to three groups: the hygromycin B premixes treatment group (n=284), the fenbendazole powder control drug group (n=284) and the no treatment and infected control group (n=256). The test period is determined according to the clinical effect. The results showed that when 10mg/kg hygromycin B premixes was fed continuously for 21 days, the deworming rate in chicken roundworms and tapeworms was about 63% and 26%, respectively, showing a significant effect on expelling roundworms (p<0.05). When fed continuously for 42 days, the rough deworming rate in chicken roundworms and tapeworms was 100% and -13%, respectively, showing an extremely significant effect on expelling roundworms(p<0.01). The coarse deworming rate in chicken roundworms and tapeworms with 50mg/kg control drug fenbendazole powder feeding continuously for six days was 100% and 44%, respectively, also showing an extremely significant role in expelling roundworms (p<0.01). In the test, the effect of these two drugs driving out roundworms was similar, while their role in expelling tapeworms was not obvious (p>0.05). 10mg/kg hygromycin B Premixs with feeding continuously for 42 days can dispel chicken roundworms completely, but has no obvious effect on expelling chicken tapeworms. |
| Key words: Chicken Ascaris Hygromycin B Clinical Trials |
