| 摘要: |
| 采用流化床制粒、包衣技术制备盐酸沃尼妙林预混剂，正交试验法进行工艺参数的筛选，通过包衣效果试验和稳定性试验进行考察，筛选出最佳生产工艺。在此优化工艺条件下制得的盐酸沃尼妙林预混剂临床适口性好、质量稳定。本品处方合理，制备工艺简单，为大规模生产提供了依据。 |
| 关键词: 盐酸沃尼妙林 制粒包衣 正交试验 |
| DOI： |
| 投稿时间：2016-04-08修订日期：2016-06-06 |
| 基金项目:石家庄市科学技术研究与发展计划课题项目(12350064A) |
|
| Preparation and Evaluation of Valnemulin Hydrochloride Premix |
|
| (Hebei Yuanzheng Pharmaceutical Co,Ltd) |
| Abstract: |
| The mixture preparation of valnemulin hydrochloride by fluidized bed granulation, pre coating technology, selection of process parameters by orthogonal test, were investigated by coating effect test and stability test, screened the best production process. Valnemulin hydrochloride premix producted under the optimized process conditions have clinical good palatability and stable quality. This prescription is reasonable, the preparation process is simple and provides a basis for mass production. |
| Key words: valnemulin hydrochloride granulating coating orthogonal test |
