盐酸咪唑苯脲复乳制备条件的优化研究

Optimization of Preparating Imidocarb Dihydrochloride Multiple Emulsion

关键词:  盐酸咪唑苯脲  复乳  配方  乳化条件

Key words:  Imidocarb Dihydrochloride  Multiple Emulsion  Recipes  Emulsification Conditions

摘要:

目的 优化盐酸咪唑苯脲复乳制剂的配方和乳化条件。方法 通过单因素筛选试验,确定最佳油相和乳化剂的种类、浓度及油水比例、乳化条件确定初乳制备条件；通过选择不同外水相乳化剂,外水相与初乳体积比,内水相稳定剂及其用量,乳化条件确定复乳制备条件。结果 选择白油作为油相、10%的OP-10为乳化剂、油相和水相比例7:3,乳化温度为40℃,乳化时间为3min,乳化速度为10000rpm时为制备乳剂的最佳条件；选择7%浓度的外水相乳化剂,外水相与初乳体积比为5:5,选择10%明胶液稳定剂,采用25℃、1min、4000rpm的乳化条件制备的复乳制剂效果最佳。结论 初步优选获得了盐酸咪唑苯脲复乳制剂配方和乳化条件。

Abstract:

Objective To optimize the recipes and conditions of preparing Imidocarb Dihydrochloride multiple emulsion. Methods Firstly, the best oil phase and emulgator and their concentrations, the oil-water proportion and emulsification conditions were determined for original emulsion preparation by means of orthogonal experiments as well as single element experiments. Secondly, the best emulgator of outside aqueous phase, the volume ratio of aqueous phase and original emulsion, stabilizer of inside aqueous phase and it’s dosage, and emulsification conditions were screened out for preparating Imidocarb Dihydrochloride multiple emulsion. Results The optimum conditions for original emulsion preparation were obtained by using mineral oil as oil phase, 10% of OP-10 as emulgator, 7:3 of oil-water proportion and the emulsification conditions were 40℃, 3min and 10000rpm. The optimal choices for multiple emulsion preparation were 7% of emulgator for outside aqueous phase, 5:5 of aqueous phase and original emulsion, 10% gel as stablizer and 25℃, 1min and 4000rpm emulsification. Conclusion The optimized the recipes and conditions of preparing Imidocarb Dihydrochloride multiple emulsion were determined.