益生菌防治畜禽细菌性肠炎作用机制的研究进展

Research progress on Mechanisms of Probiotics on Prevention and Treatment of Livestock bacterial enteritis

关键词:  益生菌  黏附  抑菌物质  黏膜屏障  免疫应答

Key words:  Probiotics  adhesion  Antibacterial substances  Mucosal barrier  Immune response

摘要:

益生菌是一类对宿主机体有益、安全无害的活微生物,代替抗生素和疫苗广泛用于畜禽细菌性肠炎的防治。益生菌主要通过与病原菌竞争黏附位点、分泌抑菌物质、加固肠道黏膜屏障、调节肠道免疫应答等抑制病原菌增殖,缓解肠道炎症,防治细菌性肠炎的发生。本文对益生菌的作用机制进行了详细阐述,为益生菌的研究和应用提供理论支持。

Abstract:

Probiotics were a class of safe, harmless and live microorganisms which are beneficial to the host organism. They were widely used in the prevention and treatment of livestock bacterial enteritis instead of antibiotics and vaccines.Probiotics can inhibit pathogen growth, alleviate intestinal inflammation and prevent the occurrence of bacterial enteritis by competing adhesion sites with pathogens、secreting antimicrobial substances、enhancing the epithelial barrier, regulating the intestinal immune responses.In this paper, the mechanism of probiotics has been elaborated to provide the oretical support for the research and application of probiotics.