鹿复合麻醉剂对鹿生理指征、ANP和CGRP的影响

Effect of the Compound Anesthetic for Deer on the Physiological Indications, ANP and CGRP in Deer

关键词:  鹿复合麻醉剂  鹿  血流动力学  心钠素  降钙素基因相关肽

Key words:  the combined anesthetic for deer  deer  hemodynamics  atrial natriuretic peptide  calcitonin gene related peptide

摘要:

研究鹿复合麻醉剂对鹿生理指征、血浆心钠素（ANP）及降钙素基因相关肽（CGRP）的影响，明确药物对机体作用，指导药物的临床应用。试验选取6只健康成年梅花鹿，肌注鹿复合麻醉剂0.04 mL/kg，注药前及注药后15、30、45、60、75、90及120 min进行收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）和心率（HR）的监测，并同步采集颈静脉血样，酶联免疫吸附法测定血浆中ANP和CGRP含量。结果表明，鹿复合麻醉剂引起麻醉期鹿血浆ANP和CGRP含量变化，使血管发生舒缩改变，导致SBP、DBP、MAP和HR产生相应的变化，苏醒后各指标均恢复到麻前水平。表明，该药物可以应用于鹿的临床麻醉。

Abstract:

Study on effect the compound anesthetic for deer on the CGRP, ANP in plasma and the physiological indications in deer, to test it’s effect on body and guide clinical application. Six healthy sika deers were injected with drug(0.04 mL/kg), systolic blood pressure (SBP), diastolic blood pressure(DBP), mean arterial pressure (MAP) and heart rhythm (HR) were monitored at 0, 15, 30, 45, 60, 75, 90, 120 min after administration, and jugular vein blood was collected at the same time. ANP and CGRP were determined by Elisa. Results showed that the changes of CGRP and ANP contents in plasma caused by the compound anesthetic for deer, and the blood vessels were changed, which resulted in the changes of SBP, DBP, MAP and HR during the period of the anesthesia. After recovery, the indexes were restored. It was concluded that the drug can be used in clinical anesthesia for deer.