夏枯草注射液对大鼠的长期毒性研究

Effects of Prunella vulgarisSinjection on the long-term toxicity of rats

关键词:  夏枯草注射液  大鼠  长期毒性

Key words:  SPrunella vulgarisSinjection  Srats  Slong-term toxicity

摘要:

为了解长期使用夏枯草注射液对机体的毒性反应,以便指导临床长期用药的安全性。给大鼠肌肉注射夏枯草注射液,在给药4周和停药2周内,观察大鼠一般行为活动等情况,进行血液学、血液生化学和主要脏器病理学检查,考察夏枯草注射液给药的长期毒性。结果显示,各组大鼠在给药期间和恢复期内, 大鼠一般情况和行为活动、粪便等均无异常变化,血液学、血液生化学和主要脏器病理学检查,均无明显变化。因此,连续大鼠肌肉注射夏枯草注射液未见明显毒性反应,说明夏枯草注射液的安全性大。

Abstract:

In order to understandStheStoxicSreactionSandSdegree on organism ofSrats by long-term useSof Prunella vulgaris injection,Sso as to we can guide theSlongterm clinicalSmedicationSsafety.SRats were givenSPrunella vulgaris injection by intramuscular route,Sat the end of 4 weeks and within 2 weeks, observing theSgeneralSbehaviourSof rats,Susing techniquesSof hematology and biochemical experimental,SinvestigatingStheSlong-term toxicity of Prunella vulgaris injection.SThe results showed that the general conditions, activities and Sfaeces of the rats thatSboth in theSdosing periodSand recoverySperiod had no abnormal change, hematology, biochemical experiment andSpathological examination ofSmainSorgans had no obvious abnormal change.STherefore,ScontinuousSintramuscular injectionSof Prunella vulgarisShad no obviousStoxicity,Swhich showed the Prunella vulgaris injectionSwere safety.