舒巴坦匹酯在肉鸡体内药物动力学研究

Studies on Pharmacokinetics of Sulbactam pivoxyl in Broiler

关键词:  舒巴坦  高效液相色谱  肉鸡  药物动力学

Key words:  sulbactam  HPLC  broiler  pharmacokinetics

摘要:

本试验主要研究舒巴坦匹酯在肉鸡体内的药物动力学特征和生物利用度,为兽医临床用药提供依据。将20羽成年三黄肉鸡随机分成两组,采用单一两期交叉试验设计分别舒巴坦钠静注、舒巴坦匹酯口灌给药,利用高效液相色谱法测定血浆中药物浓度。静脉注射舒巴坦钠(舒巴坦3.75 mg/kg.B.W)后,主要药物动力学参数：t1/2α为0.090 ± 0.001 h,t1/2β为0.919 ± 0.011 h,AUC为6.137 ± 0.376 μg.h/mL,CLb为0.611 ± 0.051 L/h/kg。舒巴坦匹酯口灌给药后(舒巴坦3.75 mg/kg.B.W),舒巴坦匹酯主要药动学参数：t1/2ka为0.087 ± 0.007h,t1/2β为2.044 ± 0.165h,AUC为4.109 ± 0.364μg.h/mL,Tmax为0.412 ± 0.039h,Cmax为1.212 ± 0.092μg/mL。鸡口灌舒巴坦匹酯后,吸收迅速,分布较快,消除也较快,舒巴坦匹酯的F为66.96% ± 5.95%。

Abstract:

The experiment mainly studied pharmacokinetics and bioavailability of sulbactam pivoxyl in broilers, providing the basis for clinical uses of veterinary drugs. (Method) 20 feather adult Sanhuang broilers were randomly divided into two groups, using a single two-period crossover experiment design, respectively by intravenous injection of sulbactam and oral administration of sulbactam pivoxyl, and adopting high performance liquid chromatography to determine concentrations of this drug in plasma . (Result) After the intravenous injection of sulbactam sodium(sulbactam 3.75 mg/kg.B.W)，the main pharmacokinetic parameters were as follows: t1/2α was 0.090 ± 0.001 h, t1/2β was 0.919 ± 0.011 h, AUC was 6.137 ± 0.376 μg ? h/mL, CLb was 0.611 ± 0.051 L/h/kg. And after sulbactam pivoxyl was orally administrated (sulbactam 3.75 mg/kg.B.W), the major pharmacokinetics parameters of this drug were as follows: t1/2ka was 0.087 ± 0.007h, t1/2β was 2.044 ± 0.165h, AUC was 4.109 ± 0.364 μg ? h/mL, Tmax was 0.412 ± 0.039h, Cmax was 1.212 ± 0.092 μg/mL. (Conclusion) After oral administration of sulbactam pivoxyl, this drug was absorbed quickly, distributed faster, and also eliminated faster, and the bioavailability of sulbactam pivoxyl was 66.96% ± 5.95%.