盐酸多西环素注射液在猪体内药效-药代动力学研究

Pharmacokinetics of Doxycycline Hydrochloride Injection in Swine after Intramuscular Injection

关键词:  多西环素  药代动力学  药效学  猪  UPLC

Key words:  doxycycline  pharmacokinetics  pharmacokinetics  swine  UPLC

摘要:

为研究了自制的盐酸多西环素注射液在健康猪的药效-药代动力学。，对10头健康猪单次肌肉注射肌内注射盐酸多西环素注射液后，采用UPLC法测定血浆中药物浓度，利用药代动力学软件WinNonlin进行数据处理。结果显示，主要药代动力学参数：消除相半衰期HL_Lambda_z为(（31.3±9.2)） h，达峰时间T max为（(0.80±0.7)） h ，峰浓度Cmax为（(4132±2475)） μg/L，药时曲线下面积AUC为(（88378±88095)） (μg/L)?h，平均滞留时间MRT为(（20.5±2.5)） h。PK/PD参数T>MIC为24 h，AUC/MIC>50，表明该制剂以10 mg?/kg-1 剂量肌肉注射肌内注射，给药间隔为两天一次。

Abstract:

Pharmacokinetics and pharmacodynamicsof a single dose of self-made doxycycline hydrochloride injection in healthy swines was studied. 10 healthy swines received 10 mg?/kg-1 of doxycycline hydrochloride intramuscularly. The concentrations of drug in plasma were determined by UPLC and the pharmacokinetics parameters were calculated by WinNonliln software. The main pharmacokinetics parameters were as follow: HL_Lambda_zelimination half lifewere was (31.3±9.2) h, Tmax, Cmax, AUC, MRT were (0.80±0.7) h, (4132±2475) μg/L, (88378±88095) (μg/L)?hand (20.5±2.5) h, respectively. And PK/PD parameter of T>MIC was 24 h and AUC/MIC>50. The doxycycline hydrochloride injectionintramuscularly given to swineby 10 mg?/kg-1 and the dosing inteval withonce per two days was recommended.