| 摘要: |
| 为进一步临床试验和了解烟酸黄藤素注射液的安全性,对其进行了溶血性试验、肌肉刺激性试验和急性毒性试验(口服试验和腹腔注射试验)。结果表明,烟酸黄藤素注射液对兔红细胞不产生溶血和凝聚作用；肌肉注射,两兔4块股四头肌刺激反应级和为3,局部刺激反应轻微；口服、腹腔注射LD50分别为2866 mg/kg、153 mg/kg,黄藤素口服给药属低毒性药物,注射给药属中等毒性药物。 |
| 关键词: 烟酸黄藤素 溶血性 刺激性 急性毒性 半数致死量 |
| DOI： |
| 投稿时间：2014-02-11修订日期：2014-04-04 |
| 基金项目:广西壮族自治区财政厅、科技厅基本科研业务费专项(桂科专项12-1)。 |
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| Safety Experiment of Nicotinic Acid Fibrauretinum Injection |
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| (Guangxi Veterinary Research Institute,Guangxi Key Laboratory of Animal Vaccine and New Technology) |
| Abstract: |
| In order to study the clinical effect and the acute toxicity of Nicotinic acid fibrauretinum injection,the hemolytic, irritation, acute toxicity(oral and intraperitoneal injection tests were included) and media lethal dose of Nicotinic acid fibrauretinum injection was tested. The results showed that the Nicotinic acid fibrauretinum injection didn’t induce the rabbit erythrocytes hemolysis and blood clotting. For intramuscular injection, the four quadriceps stimulastion level of two rabbits are 3, indicated that local irritation reactions were mild. Oral LD50 intraperitoneal injection were 2866mg/kg、153mg/kg. The results showed that the Nicotinic acid fibrauretinum belonged to low toxicity drugs by oral adminstration and injection was moderately toxic drugs. |
| Key words: Nicotinic acid fibrauretinum Hemolytic Irritation Acute toxicity Media lethal dose |
