| 摘要: |
| 在免疫毒素药物ONTAK基础上,从免疫毒素构建、纯化筛选、活性研究方面对近年来白喉毒素重组免疫毒素的研究内容进行了汇总分析,进一步得出开发受体亲和力强而细胞内毒副反应弱的融合蛋白是重组白喉毒素构建和临床应用的重要方向。 |
| 关键词: 白喉毒素 免疫毒素 癌症治疗 |
| DOI： |
| 投稿时间：2014-01-09修订日期：2014-05-03 |
| 基金项目:长春市科技局项目 |
|
| Studied on the activity of recombinant diphtheria toxin |
|
| (College of life science. Jilin Agriculture University) |
| Abstract: |
| Based on the immunotoxin drug ONTAK, we carried on the summary analysis from the construction of immunotoxins, purification filters, active research of diphtheria toxin recombinant immunotoxin in recent years. Then we come to the conclusion, fusion protein which has strong receptor affinity and weak toxicity diphtheria toxin-related is an important direction of fusion toxin build and clinical applications. |
| Key words: diphtheria toxin immunotoxin cancer therapy |
