家蝇基因工程抗菌肽的研究进展

Research progress of Musca domestica antimicrobial peptides obtained by Genetic Engineering

关键词:  家蝇  抗菌肽  基因工程  生物活性

Key words:  Musca domestica  antibacterial peptide  gene engineering  biological activity

摘要:

家蝇抗菌肽因具有独特的防御机制且不易产生耐药性而成为国内外科研工作者的研究热点，其在动物疫病防治上的应用也越发引人关注。利用基因工程技术获取家蝇抗菌肽能克服传统方法产量低、耗时长、无法实现大规模生产等缺点，是目前获取家蝇抗菌肽最为有效的方法。对家蝇基因工程抗菌肽的分类、编码基因的获得和表达以及生物活性方面进行了综述，以期为兽医临床早日研制出高效、低毒且不易产生耐药性的新兽药提供参考。

Abstract:

Musca domestica antibacterial peptide is hard to produce drug resistance with a unique defense mechanism that has become a research hotspot by researchers all over the world, and its application on animal disease prevention increasingly cause for concern. The engineering techniques is the most effective way to obtain the Musca domestica antibacterial peptide that has overcome the disadvantages of traditional method that low yield, time-consuming and can not achieve large-scale production. The classification of Musca domestica antimicrobial peptide by gene engineering, acquisition and expression of the encoding gene and biologically active are reviewed,in order to provide a reference for developing new veterinary medicine which is efficiency, low toxicity and low drag-resistance in veterinary clinical early.