| 摘要: |
| 金黄色葡萄球菌凝集因子A (ClfA) 能介导金黄色葡萄球菌粘附于基质蛋白，从而感染宿主。综述了近年来关于ClfA的结构、功能及应用等方面研究进展，为深入研究金黄色葡萄球菌的致病机制和发展新的抗感染策略提供参考。 |
| 关键词: 金黄色葡萄球菌；凝集因子A 粘附；功能；结构 |
| DOI： |
| 投稿时间：2013-04-12修订日期：2013-06-18 |
| 基金项目:吉林省教育厅“十二五”科学技术研究项目(吉教科合字[2013]第67号); 吉林农业大学科研启动基金资助项目(201220) |
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| Progress in Study of Staphylococcus aureus Clumping Factor A |
|
| (College of Animal Science and Technology,Jilin Agricultural University;China) |
| Abstract: |
| Clumping factor A (ClfA) was an important adhesin of Staphylococcus aureus that mediated bacteria adhering to extracellular matrix and also promoted clumping of bacteria in the presence of soluble fibrinogen. This paper made a general overview of research progress on the structure, functions and applications of ClfA of Staphylococcus aureus. The findings provided important leads toward the development of new therapeutic agents capable of eradicating Staphylococcus aureus carriage in individuals and interfering staphylococcal infection efficiently. |
| Key words: Staphylococcus aureus clumping factor A adhesin function structure |
