磷酸替米考星对姜曲海品系仔猪的安全性试验研究

The safety test of tilmicosin phosphate in the target animal swine

关键词:  磷酸替米考星  猪  安全性试验

Key words:  tilmicosin phosphate  swine  the safety test

摘要:

为客观评价磷酸替米考星可溶性粉对靶动物猪临床使用过程中的安全性,同时为其临床应用提供试验依据,本试验选取50头40日龄健康断奶姜曲海品系仔猪,分别以1倍剂量(80 mg/L)、3倍剂量(240 mg/L)、5倍剂量(400mg/L)以及10倍剂量(800 mg/L)的10%磷酸替米考星可溶性粉连续饮水给药21 d,检测喂服不同剂量10%磷酸替米考星可溶性粉前后受试猪的血液常规、血液生化、血凝、尿常规、料重比等指标以及进行剖杀猪的病理组织学观察。结果表明,受试仔猪没有表现出明显的不良临床症状,除10倍剂量受试猪的血清生化指标中的血清钙、血清肌酸激酶与空白对照组相比有明显差异以外,其它各用药组受试猪的血液常规、血液生化、血凝、尿常规、料重比等指标与空白对照组试验猪没有显著差异或相关指标测定值均位于正常值范围,未出现与用药明显相关的不良状况。说明10%磷酸替米考星可溶性粉毒性程度较小,受试猪体的耐受性高,至少以10倍推荐剂量连续饮水给药21 d对靶动物猪是安全的。

Abstract:

To evaluate safety of tilmicosin phosphate in the clinical use on the target animal swine and provide experimental basis for clinical application, fifty 40-days old Jiang Qu Hai piglets were selected and administrated tilmicosin phosphate continuously with one fold dose (80 mg/L), three fold dose (240 mg/L), five fold dose (400mg/L) and ten fold dose (800 mg/L) in drinking water for 21 days. The parameters of experimental piglets, such as blood routine, blood biochemistry, blood coagulation, urine routine, feed gain ratio and histopathological observation were tested before and after the experiment. The results showed that there is no obvious clinic symptoms in experimental piglets. Expect for the serum calcium and serum creatine kinase in the piglets of the ten flod dose group (800 mg/L), the tested parameters such as blood routine, blood biochemistry, blood coagulation, urine routine, feed gain ratio and histopathological observation did not display the obvious differences compared with control group, indicating that tilmicosin phosphate is low toxic and it is safe to be administrated even with the ten fold dose (800 mg/L) on the target animal swine.