| 摘要: |
| 针对连翘酯苷稳定性较差，限制了药物制剂制备及临床应用的问题，采用环糊精包合技术研制连翘酯苷注射剂，利用研磨法制备连翘酯苷-羟丙基-β-环糊精包合物。表征分析表明包合物光谱和熔点发生变化，对光稳定性和热加速实验稳定性明显增加。高效液相色谱分析鸡静脉注射给药血药浓度，表明连翘酯苷包合物与连翘酯苷药物动力学差异较小，血液中包合态药物能较快发生脱包合作用。 |
| 关键词: 连翘酯苷 羟丙基-β-环糊精 包合物 稳定性 |
| DOI： |
| 投稿时间：2012-10-24修订日期：2013-03-19 |
| 基金项目:十二五科技支撑课题(2011BAD34B01)；国家自然科学基金（31172362）；兽医学(中医药)北京市重点实验室开放课题（BUA-TCVM-200904） |
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| Preparation of Forsythiaside-Hydroxypropyl-β-Cyclodextrin Inclusion Complex and Its Character |
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| (Beijing University of Agriculture) |
| Abstract: |
| To overcome the chemical unstablity of forsythiaside, the forsythiaside-hydroxypropyl-β-cyclodextrin inclusion complex was prepared by triturating. The inclusion complex was confirmed by the change of UV spectrum and melt temperature point. The inclusion complex has a higher stability to UV light and temperature than forythiaside itself. The inclusion complex has little effect on pharmacokinetics after injection to chickens vein.
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| Key words: forsythiaside hydroxypropyl-β-cyclodextrin inclusion complex stability |
