| 摘要: |
| 为了建立了维他昔布咀嚼片体外溶出度的测定方法，以0.8%十二烷基硫酸钠溶液为溶出介质，采用桨法（50 r/min ），用紫外-可见分光光度法测定溶出度。结果显示，维他昔布浓度在0.002496～0.017472 mg/mL范围内，与吸收度呈良好的线性关系（r=0.9995），加样回收率为102.9%（RSD为1.36%），三批样品30 min时溶出度在80%以上。建立的溶出度测定方法重现性，均一性良好，样品溶出度大于80%，可用于维他昔布咀嚼片中溶出度的测定。 |
| 关键词: 维他昔布咀嚼片 溶出度 紫外-可见分光光度法 |
| DOI： |
| 投稿时间：2012-10-08修订日期：2012-11-06 |
| 基金项目:北京市海淀区科技发展计划（K20110114C） |
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| Determination of the Dissolution of Vitacoxib Chewable Tablets |
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| (Tianjin University of Traditional Chinese Medicine) |
| Abstract: |
| The article established a method to determine the dissolution of vitacoxib chewable tablets. The dissolution was tested with the slurry method (50 r/min) in 0.8% sodium dodecyl sulfate solution as medium. The concentration of vitacoxib chewable tablets, determined by ultraviolet - visible spectrophotometry, showed a good linear relationship (r=0.9995) in the range of 0.002496 ~ 0.017472 mg/mL, and a satisfactory recovery rate as 102.9% (RSD=1.36%). The dissolution of three batches of samples was above 80% in 30 min. Therefore, the method can be used for determining the dissolution of vitacoxib chewable tablets, with good reproducibility and uniformity.
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| Key words: vitacoxib chewable tablets dissolution ultraviolet - visible spectrophotometry |
