| 摘要: |
| 为了观察苦参苍术口服液对动物的安全性,采用小鼠进行长期毒性试验,设苦参苍术口服液高、中、低3个剂量组(1mL/kg?d-1、2.5mL/kg?d-1、6.25mL/kg?d-1),同时用纯化水作用空白对照组。连续给药28天,观察各组小鼠的各项生理、病理指标变化,停药后继续观察2周。结果苦参苍术口服液中、低剂量组小鼠的各项检查和各项检测指标与空白对照组比较,均无显著性差异(P＞0.05)；停药后各组也未见药物延迟性毒性反应。表明苦参苍术口服液长期用药对小鼠无明显毒性,临床拟用剂量服用是安全的。 |
| 关键词: 苦参苍术口服液 长期毒性 安全剂量 |
| DOI： |
| 投稿时间：2012-09-24修订日期：2012-10-14 |
| 基金项目:“十一五”国家科技支撑计划（2008BADB4B00） |
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| Long-term Toxicity Test of Kushencangzhu Oral Liquid |
| 高艳艳 |
| (National Research Center for Veterinary Medicine,Luoyang,Henan) |
| Abstract: |
| In order to observe the applied reliability of Kushencangzhu oral liquid,the long-term toxicity experiment was conducted in mouse. Three treatment groups (1mL/kg?d-1、2.5mL/kg?d-1、6.25mL/kg?d-1) of Kushencangzhu oral liquid and control group were divided up. Kushencangzhu oral liquid was administered orally for 28 days. The effects of Kushencangzhu oral liquid on their physiological and pathological indexes were investigated for 6 weeks. In the long-term toxicity experiment, no significant pathological difference was found among low-dose group , middle-dose group of Kushencangzhu oral liquid and the control(P＞0.05), and toxic reaction was not observed in two weeks after drug withdrawal. Kushencangzhu oral liquid has no significant toxicity in long-term toxicity test to mouse. which inferrs that the drawing up dose is safe in clinic. |
| Key words: Kushencangzhu oral liquid long-term toxicity safe dose |
