长效土霉素注射液在猪体内的药动学及相对生物利用度研究

Pharmacokinerics and Relatively Bioavailability of Oxytetracycline Long Acting Injection in Swine

关键词:  土霉素  长效注射液  药动学  相对生物利用度  猪

Key words:  Oxytetracycline  long acting injection  pharmacokinetics  relatively bioavailability  swine

摘要:

对7头健康猪随机交叉设计进行单剂量肌肉注射国产30%长效土霉素注射液和进口20%长效土霉素注射液药动学试验，给药剂量以土霉素计均为20 mg/kg体重。用高效液相色谱法测定血药浓度，血药浓度-时间数据用MCPKP计算机程序处理。30%长效土霉素注射液和20%长效土霉素注射液主要药动学参数分别为：吸收半衰期（t1/2Ka）为（0.088?0.016）、（0.140?0.076） h；消除半衰期（t1/2β）为（52.499?22.885）、（36.481?21.673） h；达峰时间（Tmax）为（0.609?0.100）、（0.832?0.373） h；峰浓度（Cmax）为（4.956?1.171）、（5.018?0.948） μg/mL；药时曲线下面积（AUC）为（112.483?18.135）、（109.877?19.949） mg/L?h；以20%长效土霉素注射液为对照物，30%长效土霉素注射液的相对生物利用度（F）为（105.368?26.027）%。结果表明，国产30%长效土霉素注射液与进口20%长效土霉素注射液相比，主要药动学参数无显著差异。此结论为临床合理使用该剂型提供了依据和指导。

Abstract:

The pharmacokinetics and relatively bioavailability of oxytetracycline long acting injection were investigated in 7 healthy swine by a random cross experimental design. Animals were intramuscularly administrated 30% oxytetracycline long acting injection and 20% terramycin long acting injection, all at the single dose of 20 mg/kg body weight. The plasma concentrations of oxytetracycline were determined by HPLC method. The plasma concentration-time data obtained from experiments were analyzed using MCPKP program. The main pharmacokinetic parameters for 30% terramycin long acting injection and 20% terramycin long acting injection administrated intramuscularly were as follows respectively: t1/2Ka (0.088?0.016) and (0.140?0.076) h, t1/2β (52.499?22.885) and (36.481?21.673) h, Tmax (0.609?0.100) and (0.832?0.373) h, Cmax (4.956?1.171) and (5.018?0.948) μg/mL, AUC (112.483?18.135) and (109.877?19.949) mg/L?h, F(105.368?26.027)%. These results showed that there was no significant difference between main pharmacokinetic parameters of 30% oxytetracycline long acting injection and 20% terramycin long acting injection.