党参多糖口服液对小白鼠免疫功能的影响

Effect of Codonopsis pilosula Polysaccharide Oral Liquids to Immunity Function in Mice

关键词:  党参多糖口服液  免疫调节  小鼠

Key words:  Codonopsis pilosula polysaccharide oral liquids  immunity function  mice

摘要:

给小鼠灌服不同剂量（每kg体重灌服9、5、7 g生药）的党参多糖口服液后，通过测定小鼠免疫脏器指数、网状内皮系统吞噬功能、半数溶血值等指标的变化评价其对免疫系统的作用。结果显示，党参多糖口服液可显著增强小鼠网状内皮系统的吞噬功能，提高成年小鼠脾脏指数（P<0.05），能显著增强小鼠半数溶血值，提高小鼠的血清溶血素抗体生成水平（P<0.05），说明党参多糖口服液有显著的免疫调节能力。该试验可为党参多糖口服液的临床应用提供参考。

Abstract:

In order to study the effects of codonopsis pilosula polysaccharide oral liquids to immunity function in mice , immune organ index、phagocytic function of RES and HC50 have been detected in mice.there are five groups in each test：negative control group to give the normal saline, positive control group to give ginseng oral liquids,(5g crude drug/kg), the other three groups were intragastric administration with Codonopsis pilosula polysaccharide oral liquids respectively low dose(5g crude drug/kg)、middle dose(7g crude drug/kg) and high dose(5g crude drug/kg). The results showed that compared with the control group,spleen index were increased significantly, phagocytic function of RES and HC50 were highly enhanced .Therefore,it is proved primarily that Codonopsis pilosula polysaccharide oral liquids can influence and regulate the immunity of normal mice , which can provide theortical guidance for clinical use of codonopsis pilosula polysaccharide oral liquids.