| 摘要: |
| 采用高效液相色谱法和管碟法对阿莫西林硫酸黏菌素可溶性粉中黏菌素含量方法的前处理条件（95 ℃水浴加热1 h）进行了研究。结果表明，95 ℃加热破坏阿莫西林的同时，硫酸黏菌素也产生降解，效价下降约12%，提示该前处理条件有待进一步改进。该实验可为完善该质量标准提供参考。 |
| 关键词: 硫酸黏菌素 管碟法 高效液相色谱法 |
| DOI： |
| 投稿时间：2012-08-17修订日期：2012-09-28 |
| 基金项目: |
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| Discussion on Thermal Determination Method in the Determination of Amoxicillin and Colistin Sulfate Soluble Powder |
|
| (China Institute of Veterinary Durg Control) |
| Abstract: |
| Thermal destruction (heated in water bath at 95 ℃ for 1 hour) in the determination of amoxicillin and colistin sulfate soluble powder was studied with HPLC and cylinder-plate methods. Results showed that thermal destruction not only lead to the degradation of penicillin, but also cause potency of colistin sulfate declineabout 12%. It suggested this method should be further improved. This study can provide a reference for the perfection of its quality standard. |
| Key words: colistin sulfate cylinder-plate method HPLC method |
