| 摘要: |
| 为评价新型抗球虫化合物纳川珠利的一般毒理学特性，选用昆明小鼠进行经口给药的急性毒性试验，以剂量递增法计算蓄积系数( K) , 于连续给药后第21天一次灌服1个LD50剂量, 观察各组小鼠对化合物的耐受性。结果，该化合物采用寇氏改良法计算的LD50为768mg/kg，95%可信限为644～916mg/kg，采用机率单位加权回归法（Bliss法）计算的LD50为769mg/kg，95%可信限为615～960mg/kg，计算蓄积系数为4.26，中度蓄积，耐受性试验中试验组和对照组的小鼠死亡率差异无统计学意义(P > 0. 05)，小鼠对化合物的耐受性无明显变化，可初步认为该新化合物的毒性较低, 在临床上应用相对安全，具有较好的成药性基础。 |
| 关键词: 抗球虫化合物 纳川珠利 急性毒性 蓄积毒性 |
| DOI： |
| 投稿时间：2012-07-26修订日期：2012-08-16 |
| 基金项目:国家863计划项目农业药物分子设计与产品创制,项目编号2011AA10A214 |
|
| General toxicology studies of a new anticoccidial compound Nitromezuril in mice |
|
| (Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences/Key Laboratory of Veterinary Drug Safety Evaluation and Residues Research/Key Laboratory of Animal Parasitology of Ministry of Agriculture) |
| Abstract: |
| In order to assess the potential toxicity of new anticoccidial compound Nitromezuril. The acute toxicity test of oral administration in mice was conducted. The accumulation factor( K) was calculated by gradually increasing doses. The amount of an LD50 of mice was administrated on 21th to study the tolerance of mice to the compound. The results showed that the LD50 of Nitromezuril is 768mg/kg and 769mg/kg, 95% Confidence interval is 644～916mg/kg and 615～960mg/kg by Kou's modified method and Bliss method respectively. The accumulative coefficient 4.26 is moderate accumulation. Mice mortality between test group and control group of tolerance test was no significant difference (P> 0. 05). These results indicated that the new compound is less toxic and relatively safe in clinical application. Nitromezuril has good medicine foundation. |
| Key words: anticoccidial compounds nitromezuril acute toxicity cumulative toxicity |
