LC-MS/MS在硝基呋喃类兽药残留检测中的应用

Application of LC-MS/MS in Detection of Nitrofuran Veterinary Drug Residues

关键词:  硝基呋喃  兽药残留  LC-MS/MS  应用

Key words:  veterinary drug residues  LC-MS/MS  application

摘要:

综述了目前硝基呋喃类兽药残留分析的检测现状,综述了用高效液相色谱/串联质谱(LC-MS/MS)法同时测定兽药残留中呋喃唑酮、呋喃它酮、呋喃西林、呋喃妥因的代谢物,并研究了代谢物的最低检测限。在此基础之上综述了国内外利用同位素内标法使用LC-MS/MS测定硝基呋喃类兽药残留的检测现状,及其达到的最低检测限。建立一种准确、灵敏、可靠的兽药残留分析方法,阐明了其应用对我国食品安全体系健康发展的重要意义。

Abstract:

An introduction of the present status regarding veterinary drug residue analysis has been made, the paper also made a review of a high performance liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was established for simultaneous determination of the nitrofuran metabolites,furazolidone,furaltadone．nitrofurazone and nitrofurantoin, it briefly summarized the limit of detection (LOD) and quantify-cation(LOQ) in veterinary drug residueand. Summarized isotopic internal standard method using LC-MS/MS determination, Which can be reached the lowest limit of detection in veterinary drug residue analysis at domestically and abroad. Establish a precise, sensitive and reliable method for analyzing veterinary drug residue. The paper elucidated the great importance of the application of stable isotopes in the sane development of China"s food safety system.