猪伪狂犬病灭活疫苗(HB-J株)对兔与猪免疫攻毒保护平行关系的研究试验

Study on parallel Relationship between immune and chanllenge protection of Inactivated Pseudorabies Vaccine （HB-J strain）in piglets and rabbits

关键词:  猪伪狂犬病  灭活疫苗  免疫攻毒保护  平行关系

Key words:  pseudorabies  inactivated vaccine  immune and protection  parallel relationship

摘要:

用连续研制的3批猪伪狂犬病灭活疫苗（HB-J株）分别以不同剂量免疫健康兔和断奶仔猪，检测其免疫28日后的血清抗体，并对免疫28日后的兔和断奶仔猪分别进行攻毒，统计各组兔和断奶仔猪免疫后攻毒保护率。结果表明，兔免疫28日后的血清抗体中和指数为794～1258时保护率为60%～80%，≥1479时可获得100%保护；仔猪免疫28日后的血清抗体中和指数为229～269时保护率为60%～80%，≥331时可获得100%保护；兔与仔猪对猪伪狂犬病灭活疫苗（HB-J株）均产生良好的免疫应答反应，免疫与攻毒保护呈现良好的平行关系。

Abstract:

Healthy rabbits and weaning piglets were immuned respectively with different doses of three successive bathes of swine pseudorabies inactivated vaccine (HB-J strain). 28 days after inoculation, serum antibodies were detected and healthy rabbits and weaning piglets were challenged respectively with strong PRV, and the immunity protection rate against strong virus were tested. The results showed that protection rate in rabbits was 60% to 80% and the neutralization index of antibodies was 794～1258, greater than or equal to 1479 , with protection rate of 100%; protection rate in piglets was 60% to 80% with the neutralization index of antibodies 229～269, greater than or equal to 331 with protection rate 100%; rabbits and piglets had good immune response to swine pseudorabies inactivated vaccine (HB-J strain). There was good parallel relationship between immunity level and protection.