卡洛芬注射液抗炎、镇痛效果及皮肤刺激性观察

Effects Observation of Anti-inflammatory and Analgesic and Skin Irritation of Carprofen Injection

关键词:  痛立止  托芬那酸  抗炎  镇痛  皮肤刺激性

Key words:  Meloxicam  Tolfenamic Acid  Anti-inflammatory  Analgesia  Skin irritation

摘要:

探讨卡洛芬注射液的抗炎、镇痛作用与皮肤刺激性。以市售托芬那酸注射液为对照药物，抗炎作用采用小鼠耳肿胀法、大鼠踝关节肿胀法，镇痛作用采用小鼠热板法、小鼠醋酸扭体法，刺激性采用兔的皮肤刺激试验考察卡洛芬注射液I、II的抗炎、镇痛作用与刺激性。结果显示，各给药组对二甲苯所致的小鼠耳炎具有明显的抑制作用，且与生理盐水组差异显著（P＜0.05）；可抑制甲醛所致的大鼠踝关节肿胀，托芬那酸组的肿胀抑制率最高，其次为卡洛芬I组。卡洛芬I组和托芬那酸组在15、30 min时均可有效延长小鼠热板痛阈值；卡洛芬II组没有明显镇痛效果。卡洛芬I组和II组对小鼠扭体的潜伏期没有明显改变，但扭体次数相对较少，扭体抑制率分别为34.7%和17.5%。托芬那酸组第一次扭体的潜伏期较长，扭体抑制率为42.6%。兔的皮肤刺激性试验各给药组均未出现不良反应。卡洛芬I组药效快，抗炎、镇痛效果显著，安全无刺激性，效果优于卡洛芬II组。

Abstract:

To study the effects of anti-inflammatory and analgesic analgesic and skin irritation of two kinds of Tonglizhi injections．With Tolfenamic acid injection comparison,the anti-inflammatory effects were investigated by the methods of xylol induced auriclate tumefaction on mice, carrageenin induced foot swelling on rat.The analgesic effects were observed by the hot—plate test and writhing with acetic acid in mice, and skin irritation reactions were observed in rabbits. Tonglizhi groups and Tolfenamic acid group could inhibit the mouse auriclate tumefaction induced by xylol, inhibit the rat foot swelling induced by carrageenin. The anti-inflammatory effects of Tonglizhi I group and Tolfenamic acid were better than Tonglizhi II group. the pain threshold of of Tonglizhi I group and Tolfenamic acid group at 15 minites and 30 minites were prolonged in mice. The number of writhing induced by acetic acid in mice were significantly reduced by all groups. The writhing inhibition percentages of Tonglizhi I、Tonglizhi II and Tolfenamic acid group were 34.7%、17.5% and 42.6%, respectively. The time of first writhing response of Tolfenamic acid group was prolongede. The skin irritation test"s results showed that there were no abnormal changes in rabbits. Tonglizhi I injection has a rapid and exact anti-inflammatory and analgesic effection, better than Tonglizhi II, with no skin irritation.