| 摘要: |
| 综述了基因工程菌Lactococcus lactis NZ9000在基因组学、安全性、功能性、疫苗载体构建、菌株改造等方面的研究进展，对NZ9000作为口服疫苗载体的表达系统进行了评述，展望了其在生物制药、疫苗开发和食品工业等领域的应用前景，并对今后研究的发展方向做了分析。 |
| 关键词: 口服疫苗 递送载体 乳酸乳球菌NZ9000 |
| DOI： |
| 投稿时间：2011-12-08修订日期：2012-03-15 |
| 基金项目:国家自然科学基金(81001342)；吉林省自然科学基金项目(201015116)；吉林省高新技术产业发展项目(2010)；长春市科技特派员行动计划(09KT04) |
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| Advancement of Lactococcus lactis NZ9000 as oral vaccine delivery vehicle |
| REN Da-yong |
| (College of Food Science and Engineering,Jilin Agricultural University) |
| Abstract: |
| Advance in genomics, safety, functionality, vaccine vehicle construction and strain improvement of genetically engineered bacteria Lactococcus lactis NZ9000 were reviewed. The gene expression system of NZ9000 as oral vaccine delivery vehicle were discussed and it’s application prospect in the fields of biopharming, vaccine development and food industry were proposed and it’s research development in the future was also briefly analyzed. |
| Key words: oral vaccine delivery vehicle Lactococcus lactis NZ9000 |
